Cancer breakthrough: Grape seed extract kills colorectal cancer cells

(NaturalNews) Cancer researchers are working to find chemotherapies that destroy cancer cells but are harmless to normal cells. It turns out, a natural substance already exists that does just that. University of Colorado Cancer Center scientists have just published a study in the journal Cancer Letters that shows grape seed extract (GSE) is a powerful weapon against colorectal cancer. It halts the growth and survival of colorectal cancer cells and kills them in large numbers, too, while leaving healthy cells completely alone.

And the news about GSE gets better: the more advanced the colorectal cancer cells, the more GSE shuts down the malignant cells' growth and survival. The scientists think that GSE targets colorectal cancer by causing oxidative stress that leads to the programmed cell death known as apoptosis.

"We've known for quite a while that the bioactive compounds in grape seed extract selectively target many types of cancer cells. This study shows that many of the same mutations that allow colorectal cancer cells to metastasize and survive traditional therapies make them especially sensitive to treatment with GSE," Molly Derry, doctoral candidate in the lab of Rajesh Agarwal, PhD, investigator at the CU Cancer Center and professor at the Skaggs School of Pharmacy and Pharmaceutical Sciences, said in a press statement.

Derry pointed out that the GSE findings are especially important due to the increasing rates of colorectal cancer. Unfortunately, 60 percent of patients diagnosed with this form of cancer have already reached the advanced stage of the disease.

As the research team performed their experiments on colorectal cancer cell lines representing all stages of the disease, they came up with another startling finding. Although it usually takes much more chemotherapy to kill a stage IV cancer cell than a stage II cancer cell, the exact opposite was true when it came to grape seed extract.

"It required less than half the concentration of GSE to suppress cell growth and kill 50 percent of stage IV cells than it did to achieve similar results in the stage II cells," Derry revealed in a media statement.

"A colorectal cancer cell can have upwards of 11,000 genetic mutations -- differences from the DNA in healthy cells. Traditional chemotherapies may only target a specific mutation and as cancer progresses more mutations occur. These changes can result in cancer that is resistance to chemotherapy. In contrast, the many bioactive compounds of GSE are able to target multiple mutations. The more mutations a cancer presents, the more effective GSE is in targeting them," Derry added.

The Agarwal Lab studies the effectiveness and action of dietary compounds against cancer and is encouraging further exploration of their findings in clinical settings with patients. "Finding a way to selectively target advanced colorectal cancer cells could have major clinical importance," Derry stated.

As NaturalNews previously reported, researchers from the University of Kentucky have also conducted groundbreaking research into the anti-cancer properties of grape seed extract. They found the natural substance triggered the death of 76 percent of leukemia cells exposed to the extract in a laboratory experiment. Their study, published Clinical Cancer Research, a journal of the American Association for Cancer Research, showed that grape seed extract triggered the destruction of leukemia cells by apparently "turning on" a protein known as JNK that regulates the cancer cell killing pathway.

Sources:

http://www.cancerletters.info/article/S0304-3835(12)00732-X/abstract
http://www.coloradocancerblogs.org
http://www.naturalnews.com 
http://www.sciencedirect.com/science/article/pii/S030438351200732X

Prevent Colon Cancer With 5 Easy Ways

Research studies are now going on how best to prevent colon cancer as more and more people are diagnosed with this condition today. It is found that colon cancer usually starts in the large intestine, also known as colon, or the rectum. Colon cancer then develops from dead cells that have been accumulated in a lump over a period of time. The risk to getting colon cancer increases if you have a genetic medical background of parents or close relatives who have been diagnosed with colon cancer. Research also showed that that colon cancer is aggravated by unhealthy diets such as ready meals and fast food.
Hence, it is vital that you seek the advice of your doctor should you feel the discomfort of colon cancer symptoms. The symptoms to look out for include unhealthy bowel occurrence such as diarrhea, constipation or bowel infection, severe pain in abdomen, blood in the stools, narrow stools, anemia, intestinal obstruction and drastic loss of weight.
Prevention is still better than cure. So you really should consider the following 5 ways on how best to prevent colon cancer:
1. Adopt healthy habits. Colon cancer usually develops over a length of period before it actually shows. Hence you should not wait till you notice the symptoms of colon cancer before starting to adopt healthy habits. Eat healthy meals, exercise and have an adequate amount of sleep.
If your diet contains too much high fat and red meats with little fiber, you are definitely at a high risk of developing colon cancer. Fat accumulates on the walls of the intestine and rectum, forming lumps of dead cells. You should therefore adopt a balanced natural diet which includes lots of green vegetables, fruits and water.
Exercise helps by flushing out harmful toxins and waste matter which if left accumulated in your body can cause cancerous growth.
2. Know your family medical history. It appears that colon cancer is a genetic disease that is hereditary. As such, if you belong to the high risk category due to your family history, then you should take extra precautions by leading a healthy lifestyle.
3. Stop smoking. Chain smoking increases your chance to developing colon cancer. Inhaling tobacco can easily transfer carcinogen (a cancer agent) to your colon and rectum, thus resulting in colon cancer. Hence, do not hesitate to find ways to quit smoking.
4. Reduce exposure to radiation. Excessive exposure to radiation has been found to cause colon cancer. Radiation rays are harmful and can render healthy normal cells abnormal. By all means, avoid unnecessary X-rays, CT scans, mammograms so that you can best prevent colon cancer.
5. If you observe that you are experiencing symptoms like skin allergies, weak immune system, poor movement of bowels, bloating, etc, then it may be that you have too much toxins in your body. Consider colon cleansing as a way of detoxification. There are a couple of ways to perform colon cleansing. These include consuming herbs for colon cleansing and colon hydrotherapy.

By Sandra Kim Leong