Showing posts with label brain tumor. Show all posts
Showing posts with label brain tumor. Show all posts

What Does That Headache Mean?

Headache is one of the most common medical complaints. Almost everyone experiences a headache from time to time. In the large majority of cases, it is a completely benign condition which is a nuisance and does not represent any significant or long-term medical problems. However, many people worry about a headache and are concerned that it could imply something much more serious. We all know the old "It's not a too-mah!" line and joke about it, but what do headaches really mean? Can they mean something more serious?
The answer is a definitive yes. Some very serious medical conditions can be associated with headache. However, I must state again that the very large majority of headaches do not imply anything serious. While millions, if not billions, of people on this planet experience headache in their lifetime, only a small percentage will every have a more serious, related condition diagnosed.
So how do you know? What does that headache mean? That is not an easy question to answer. In fact, there are physicians who spend their whole career specializing specifically in headache, its causes and its treatments. While there is no easy answer that covers all possibilities, this article will supply you with a handful of the most common causes and types of headaches, from the most harmless and benign to the medical emergencies. It will explain some of the differences that help to distinguish one type of headache from another. This is not an exhaustive list of every possible cause of headache, there are certainly others. It starts with some of the more common causes and moves on to more rare causes.
This article is not intended to offer medical advice. Every patient and headache is different. Only your personal physician can help counsel you about what is best for your particular situation. If you are concerned about a headache or headaches you are having, consult your doctor.
Stress/Tension Headache
By far the largest majority of headaches that most people experience are what is known as a Tension Headache, or some similar variant. While the exact cause of these headaches is not known and probably varies from patient to patient, this benign type of headache is usually associated with stress and muscle tension or spasm of the neck, facial or head muscles. While their severity, location and characteristics can vary, they are almost always harmless and do not represent any more serious underlying problem. This is the typical headache most of us have experienced when you are over-tired, over-worked, or stressed. Tension headaches do not cause other neurological symptoms. If other symptoms are present, it should raise the question of another diagnosis.
Sinus Headache
The paranasal sinuses are mucosa-lined chambers in the bone of the skull and face. There are several of them surrounding the nasal passages. Normally, mucous secretions that are produced in the sinuses flow out of openings into the nasal passage. However, if a sinus is obstructed so that its contents cannot exit, the pressure inside the sinuses can build up. This can occur with mucosal swelling associated with allergy (allergic rhinitis or hay fever) or with infection such as a cold or sinus infection. When pressure builds up inside a sinus, it can cause pain. While some sinuses (such as the large maxillary sinuses) are in the face, most are associated with the base of the skull. This pain can be interpreted and described as headache. While these sinus headaches can occur in anyone with a "stuffed nose" of any cause, patients who have chronic sinus problems with recurrent sinus infections can often have quite severe pain associated with this condition.
Migraine Headache
A migraine headache is a specific type of headache which is thought to be of vascular or neurologic origin. They are more common in women and in some patients can occur regularly, often following a particular part of the menstrual cycle. While they traditionally are described as causing pain on only one side of the head, they can occasionally cause pain on both sides of the head as well. In addition to the headache, other neurological symptoms usually accompany the headache. For example, many patients describe having an "aura" prior to the onset of the headache. These can vary but the patient generally has some symptom that lets them know a headache is coming. They can even experience seemingly focal neurological symptoms such as a scatoma (a temporary blind spot in their field of vision) or other visual changes. Photophobia, avoiding bright lights, can occur as well. Finally, many patients experience nausea and even vomiting. All of these neurological effects do not occur in a typical tension headache and help to distinguish migraines. However, some of the symptoms of migraine, particularly the nausea and vomiting and photophobia, are similar to symptoms of more serious causes of headache such as subarachnoid hemorrhage or meningitis. Therefore, those more serious disorders should be ruled out before classifying a headache as a migraine.
Cluster Headache
Cluster headaches are a unique neurological form of headache with an unknown cause. These extremely painful attacks are usually only on one side and is often described as a stabbing or boring pain that is located behind the eye. It usually occurs suddenly and periodically, followed by periods of remission. In addition to pain, which can be extraordinarily severe and one of the most painful conditions a human can endure, cluster headaches are characterized by symptoms that seem to come from the autonomic nervous system. These include ptosis (a drooping eyelid on the same side), tearing, runny nose, redness of the eye and even facial redness, swelling and/or sweating. These symptoms all occur only on the same side as the headache. Some patients describe certain triggers that set off attacks, such as ingestion of alcohol or exposure to heat.
Meningitis
Meningitis is an infection of the coverings of the brain, the meninges, and the fluid surrounding the brain and spinal cord, the cerebrospinal fluid. It can be caused by viruses or by bacteria. While the bacterial form is much more dangerous and has the potential to lead to severe neurological injury and death if not treated promptly, both have similar presentations. Both cause headache as one of the hallmark symptoms. Because of the infection and severe inflammation of the coverings of brain, any movement of the head and neck can be very painful. Generally it is a severe headache (with or without a back ache as well) that progresses rapidly and is accompanied by a high fever. The patient generally has a very stiff, painful neck as well, called nuchal rigidity. It is so painful that they keep their neck very rigid to prevent any movement, even if they are lethargic or unconscious. Photophobia, as with migraines and subarachnoid hemorrhage, and seizures can occur as well. In the case of bacterial meningitis, these symptoms can quickly escalate to a progressively deteriorating level of consciousness, coma and eventually death if not treated quickly. The combination of high fever, headache, stiff neck and/or lethargy should be considered concerning for meningitis until proven otherwise. Untreated bacterial meningitis can progress quickly and can be life-threatening. Thankfully it is relatively rare.
Subarachnoid Hemorrhage
Subarachnoid hemorrhage means bleeding into the space around the brain into the cerebrospinal fluid. While this can occur with trauma to the head, it can happen spontaneously due to the rupture of an intracranial aneurysm. An intracranial aneurysm is an abnormal bulging of the wall of an artery that feeds the brain. These weakened blood vessels have a tendency to rupture and bleed. This type of bleeding typically causes a sudden-onset of severe headache. Most patients describe it as the "worst headache of my life." It comes on very suddenly and is usually of a stabbing quality. It can be accompanied by nausea, vomiting, seizures, stiff, painful neck and/or a depressed level of consciousness. In severe bleeds it can even lead to coma or sudden death. In patients who have a history of chronic headaches, such as migraines or cluster headaches, they will generally say that the character of this headache is different. Therefore, a sudden, intense, new headache, particularly if associated with any of the other symptoms, should be considered a ruptured aneurysm until proven otherwise. An aneurysm rupture, like bacterial meningitis above, is generally a medical emergency. An aneurysm which has ruptured is at increased risk of re-rupture. Often the second rupture is more severe and more devastating than the first. Again, this is a rare cause of headache, but a potentially deadly one.
Brain Tumor
While the brain itself does not cause pain, increased pressure inside the head or irritation of the coverings of the brain can cause headache. With a brain tumor that does either, one of the presenting symptoms of these tumors can be headache. Most types of brain tumor, whether primary or a metastases from another tumor elsewhere in the body, can cause this symptom. A new headache in the setting of new neurological symptoms should raise red flags. Other symptoms that can accompany a brain tumor are seizures, changes in vision, or sensory or motor symptoms such as weakness of a part of the body. Many different neurological symptoms are possible depending on the type and location of the tumor. Headache that is caused by increased pressure in the head is often worse in the morning or will wake the patient from sleep, getting better when upright and awake. Again, this is a rare cause of headache, but clearly one which is potentially a very serious condition.

Brain Cancer - Symptoms of Brain Cancer

Brain cancer is a disease of the brain where cancer cells (malignant) grow in the brain tissue. Cancer cells grow to form a mass of cancer tissue (tumor) that interferes with brain tissue functions such as muscle control, sensation, memory, and other normal body functions. Tumors composed of cancer cells are called malignant tumors, and those composed of noncancerous cells are called benign tumors. Cancer cells that develop from brain tissue are called primary brain tumors. Statistics suggest that brain cancer is not rare and is likely to develop in about 20,000 people per year.
There are two main types of brain cancer. Primary brain cancer starts in the brain. Metastatic brain cancer starts somewhere else in the body and moves to the brain. Brain tumors can be benign, with no cancer cells, or malignant, with cancer cells that grow quickly.
Primary brain cancer rarely spreads beyond the central nervous system, and death results from uncontrolled tumor growth within the limited space of the skull. Metastatic brain cancer indicates advanced disease and has a poor prognosis.
Metastatic brain tumors are made of cancerous cells from a tumor elsewhere in the body. The cells spread to the brain from another tumor in a process called metastasis. About 25% of tumors elsewhere in the body metastasize to the brain.
Symptoms of Brain Cancer
Brain tumors can damage vital neurological pathways and invade and compress brain tissue. Symptoms usually develop over time and their characteristics depend on the location and size of the tumor.
Cancers are typically painless at first. As they grow, the first symptom is often a mild discomfort, which may steadily worsen into increasingly severe pain as the cancer enlarges. The pain may result from the cancer compressing or eroding into nerves or other structures.
The symptoms are caused by the tumor pressing on or encroaching on other parts of your brain and keeping them from functioning normally.
A sign is also an indication that something is not right in the body. But signs are defined as things that can be seen by a doctor, nurse, or other health care professional. Fever, rapid breathing rate, and abnormal breathing sounds heard through a stethoscope may be signs of pneumonia.
As the skull is made of bone, there is a fixed amount of space for the brain to take up. The growing tumor increases the pressure inside this fixed space. This is called 'raised intracranial pressure'.
Motion sickness is a very common disturbance of the inner ear that is caused by repeated motion such as from the swell of the sea, the movement of a car, the motion of a plane in turbulent air, etc. In the inner ear (which is also called the labyrinth), motion sickness affects the sense of balance and equilibrium and, hence, the sense of spatial orientation.
Brain tumors can often present different symptoms depending on the location of the tumor. There are general brain tumor symptoms that need to be checked out by a doctor if they are experienced.
Fits are one of the commonest symptoms of brain tumors. About 1 in 4 people with a brain tumor first go to their doctor because they have had a fit. A fit can just be jerking or twitching of a hand, arm or leg.
At the late stages of the disorder, dramatic changes in blood pressure may occur. Seizures are a common symptom of benign brain tumors and slow-growing cancers. Tumors can cause a part of the body to weaken or feel paralyzed. Hearing, sight and the sense of smell can be affected.
Brain Cancer - Symptoms of Brain Cancer

Shock findings in new GMO study: Rats fed lifetime of GM corn grow horrifying tumors, 70% of females die early

(NaturalNews) Eating genetically modified corn (GM corn) and consuming trace levels of Monsanto's Roundup chemical fertilizer caused rats to develop horrifying tumors, widespread organ damage, and premature death. That's the conclusion of a shocking new study that looked at the long-term effects of consuming Monsanto's genetically modified corn.

The study has been deemed "the most thorough research ever published into the health effects of GM food crops and the herbicide Roundup on rats." News of the horrifying findings is spreading like wildfire across the internet, with even the mainstream media seemingly in shock over the photos of rats with multiple grotesque tumors... tumors so large the rats even had difficulty breathing in some cases. GMOs may be the new thalidomide.
"Monsanto Roundup weedkiller and GM maize implicated in 'shocking' new cancer study" wrote The Grocery, a popular UK publication. (http://www.thegrocer.co.uk/topics/technology-and-supply-chain/monsant...)

It reported, "Scientists found that rats exposed to even the smallest amounts, developed mammary tumors and severe liver and kidney damage as early as four months in males, and seven months for females."

The Daily Mail reported, "Fresh row over GM foods as French study claims rats fed the controversial crops suffered tumors." (http://www.dailymail.co.uk/sciencetech/article-2205509/Fresh-fears-GM...)

It goes on to say: "The animals on the GM diet suffered mammary tumors, as well as severe liver and kidney damage. The researchers said 50 percent of males and 70 percent of females died prematurely, compared with only 30 percent and 20 percent in the control group."

The study, led by Gilles-Eric Seralini of the University of Caen, was the first ever study to examine the long-term (lifetime) effects of eating GMOs. You may find yourself thinking it is absolutely astonishing that no such studies were ever conducted before GM corn was approved for widespread use by the USDA and FDA, but such is the power of corporate lobbying and corporate greed.

The study was published in The Food & Chemical Toxicology Journal and was just presented at a news conference in London.

Findings from the study

Here are some of the shocking findings from the study:

• Up to 50% of males and 70% of females suffered premature death.

• Rats that drank trace amounts of Roundup (at levels legally allowed in the water supply) had a 200% to 300% increase in large tumors.

• Rats fed GM corn and traces of Roundup suffered severe organ damage including liver damage and kidney damage.

• The study fed these rats NK603, the Monsanto variety of GM corn that's grown across North America and widely fed to animals and humans. This is the same corn that's in your corn-based breakfast cereal, corn tortillas and corn snack chips.

The Daily Mail is reporting on some of the reaction to the findings:

France's Jose Bove, vice-chairman of the European Parliament's commission for agriculture and known as a fierce opponent of GM, called for an immediate suspension of all EU cultivation and import authorisations of GM crops. 'This study finally shows we are right and that it is urgent to quickly review all GMO evaluation processes,' he said in a statement. 'National and European food security agencies must carry out new studies financed by public funding to guarantee healthy food for European consumers.' (http://www.dailymail.co.uk/sciencetech/article-2205509/Fresh-fears-GM...)

Read the study abstract

The study is entitled, "A Comparison of the Effects of Three GM Corn Varieties on Mammalian Health." Read the abstract here:
http://www.biolsci.org/v05p0706.htm

That abstract include this text. Note: "hepatorenal toxicity" means toxic to the liver.

Our analysis clearly reveals for the 3 GMOs new side effects linked with GM maize consumption, which were sex- and often dose-dependent. Effects were mostly associated with the kidney and liver, the dietary detoxifying organs, although different between the 3 GMOs. Other effects were also noticed in the heart, adrenal glands, spleen and haematopoietic system. We conclude that these data highlight signs of hepatorenal toxicity, possibly due to the new pesticides specific to each GM corn. In addition, unintended direct or indirect metabolic consequences of the genetic modification cannot be excluded.

Here are some quotes from the researchers:

"This research shows an extraordinary number of tumors developing earlier and more aggressively - particularly in female animals. I am shocked by the extreme negative health impacts." - Dr Michael Antoniou, molecular biologist, King's College London.

"We can expect that the consumption of GM maize and the herbicide Roundup, impacts seriously on human health." - Dr Antoniou.

"This is the first time that a long-term animal feeding trial has examined the impact of feeding GM corn or the herbicide Roundup, or a combination of both and the results are extremely serious. In the male rats, there was liver and kidney disorders, including tumors and even more worryingly, in the female rats, there were mammary tumors at a level which is extremely concerning; up to 80 percent of the female rats had mammary tumors by the end of the trial." - Patrick Holden, Director, Sustainable Food Trust.

Spread the word: GMOs are toxic!

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Delta-24-RGD - A Virus Found to Target and Eliminate Cancer Cells of the Brain

Cancer is quite a hot topic in the scientific research community today, due to the obvious lack of knowledge underlying certain biological processes. Without the mastery of these biological pathways, it is not feasible to devise surefire treatment and/or prevention methods against specific types of cancer. One does not have to look very far to find criticism or an attempt at exploitation of these biological voids by the media. Despite the frequent scrutiny, the field of oncology (the study of tumors/cancer) has improved exponentially in understanding the manifestation, diagnosis, prevention, and treatment of cancer. A simple look at the declining morbidity rates of cancer patients over the last few decades should provide some comfort even to the most skeptical individuals.
Despite the frequent advances in cancer research, the findings manage to fly under the radar of mainstream media. It lies within these small findings, which are the basis of future treatments and cures. Recently, a group of researchers came one step closer to solving their life saving puzzle.
The study, conducted by researchers at the UT-Houston M.D. Anderson Cancer Center and funded by the National Cancer Institute, analyzed the destructive effects on brain tumor stem cells of mice by introducing a tailored adenovirus (Delta-24-RDG). By tailored adenovirus, I mean a specific virus produced by scientists. This was tested on the most aggressive brain tumor, glioblastoma multiforme, which is known to be resistant to chemotherapy and radiation. The particular intrigue in this project stems from their attempt to build on well-known and studied research performed in 2003.
The 2003 study found that Delta-24 eliminated brain tumors in 60% of mice. The recent study however, was conducted on the actual stem cells that drive the continued tumor growth postoperatively, hence the testing on glioma stem cells. This led to a direct comparison in survival time between the control group (received no intervention) and the treatment group (received Delta-24 injection). The survival time of the mice who received treatment nearly doubled that of the control group. The result is obvious: the mice that received the injection of the adenovirus demonstrated prolonged life-spans. The success of the study did not simply end there.
The researchers attempted to analyze more than mere cause and effect. They sought to gain information on the actual physiological process contributing to the death of the stem cells in the brain. For the first time, adenovirus-mediated cell death (by autophagy) was noted as the direct method of cellular death in tumor stem cells of the brain. It was also noted that the therapeutic virus did not alter normal brain tissue. This finding carries with it tremendous hope because the tumors formed in the brains of these mice closely resemble brain tumors in humans. This resemblance lies in their irregular form and invasive metastatic, or spreading, properties. The study did mention the limitations of these findings and the need for further research, but it does postulate an exciting and possible method of cancer treatment, which may not be limited to the brain. This study only hints at the remarkable and constant efforts put forth by cancer researchers. One must remember that our race for a cure is not a sprint, but an ongoing marathon that must be carefully and methodically ran.
1) Fueyo J, Alemany R, Gomez-Manzano C, Fuller GN, Khan A, Conrad CA, Liu TJ, Jiang H, Lemoine MG, Suzuki K, Sawaya R, Curiel DT, Yung WK, Lang FF. Preclinical characterization of the antiglioma activity of a tropism-enhanced adenovirus targeted to the retinoblastoma pathway. J Natl Cancer Inst. 2003 May 7;95(9):652-60. PMID: 12734316.
2) Jiang H., Gomez-Manzano C., Aoki H., Alonso M.M., Kondo S., McCormick F., Xu J., Kondo Y., Bekele B.N., Colman H., Lang F.F., Fueyo J. Examination of the therapeutic potential of Delta-24-RGD in brain tumor stem cells: role of autophagic cell death. J Natl Cancer Inst. 2007 Sep 19;99(18):1410-4. PMID: 17848677.
Eliminate Cancer Cells of the Brain